Allyson J Rosati et al, found in their study that the sperm mitochondrial DNA copy number (mtDNAcn) had a predictive value to evaluate couple fecundity. This is a population-based prospective cohort study. Their data showed that “Higher sperm mtDNAcn was associated with lower pregnancy probability within 12 months and longer TTP ( time-to-pregnancy).” However, “sperm mitochondrial DNA deletions (mtDNAdel) was not associated with TTP”1.
1. Human Reproduction, Volume 35, Issue 11, November 2020, Pages 2619–2625
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